- Contains a mutant rough form of the parent organism. This product does not appear to cause undulant fever in people, but the lack of sufficient data precludes this definitively.
- In vivo studies in test animals, demonstrate growth of the organism at injection site and regional lymph nodes.
- Contact your physician. The above product (Brucella Abortus) contains live bacterial organisms. Local swelling at the injection site is possible from the bacterin or from contaminated equipment. The organism is resistant to Penicillin and Rifampin. CDC recommends the physician prescribe 100mg doxycycline BID x 21days for exposure to this organism. (See the end of page for reference material regarding Brucella abortus.)
The following is reference material regarding exposure to Brucella. The Center for Disease Control also has these articles on the website:
(Excerpt from paper: Gerhardt GG, Roop RM, Bagchi T, Boyle S, Buhrman D, and Sriranganathan N. Biological properties of RB51; a stable rough strain of Brucella abortus. Veterinary Microbiology, 28 (1991), 171-188. States: RB-51 strain was susceptible to: crythromycin, ampicillin, chloramphenicol, gentamycin, kanamycin, neomycin, oxytetracycline, carbenicillin, cephalothin, streptomycin, nitrofurantoin, tetracycline and trimethoprim/sulfamethoxazole. Resistant to: triple sulfa, penicillin, furazolidone, rifampin.
Excerpt from paper: J. Vet Pharmacol. Therap. 28, 185-201, 2005, entitled: Veterinary pharmacovigilance. Part 4. Adverse reactions in humans to veterinary medicinal products. (The 26 subjects referenced below contacted Colorado Serum Company initially, during the first year of RB-51 usage, and we forwarded on to CDC for their surveillance study): A recent study reported on humans exposed to Brucella abortus strain RB-51 via vaccination. The Centers for Disease Control (CDC) in the US conducted passive surveillance for accidental injection with exposure to the vaccine and received reports from 26 affected individuals (via Colorado Serum Company). Of these, 21 subjects had suffered needle stick injuries, while four had received conjunctival spray exposure and one an exposure to an open wound. There were no clear cases of brucellosis in these individuals, suggesting that this strain might have low pathogenicity to humans but at present, there is insufficient data to determine if the strain can cause systemic brucellosis in humans.” (Ashford et al., 2004)